Neurological & Psychological Disorders News on research and diagnostic developments in neuroscience. Protective, Risk-Linked APOE Alleles Affect Glial Cell Transcriptome The APOEε4 allele is linked to the upregulation of a phagocytosis and proinflammatory gene set both in normal aging and Alzheimer's disease brains. Orphan Gene Linked to Neurodevelopmental Disorder Characterized by Hearing Loss Through a sequencing screen of patients, researchers identified biallelic variants in SPATA5L1 that were associated with hearing loss, intellectual disability, and epilepsy. Pharmacogenomics Firm Genetika+ Raises $10M in Series A Round The company is developing a test to predict the best antidepressant drug or drug combination for a specific patient. Study on Hold The Spectrum 10K study has been put on hold due to a backlash, leading the researchers to conduct consultations with the autism community, Nature News reports. Public-Private Data Science Collaboration to ID Alzheimer's, Other Neurodegenerative Risk Factors The collaboration aims to apply imaging and genomic data to identify risk factors for Alzheimer's and related neurodegenerative disorders. Sep 7, 2021 Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis Aug 31, 2021 FinnGen Project's Role in Epilepsy, Drug Adherence Studies Showcased at ESHG Jul 27, 2021 Children With Autism May Have Underdeveloped Gut Microbiomes, Metagenomic Analysis Finds Jul 26, 2021 Gene-Disrupting Ultra-Rare Variants More Common in Children With Autism Spectrum Disorder Jul 22, 2021 Multi-Ethnic Migraine GWAS Uncovers Risk Loci Specific to Sex, Ancestry Jun 28, 2021 Obsessive Compulsive Disorder Exome Analysis Uncovers Contributions From Rare Coding Variants Jun 23, 2021 Infinity BiologiX to Offer Cytox Alzheimer's Disease Genetic Risk Test in US Jun 17, 2021 GWAS Reveals New Loci Linked to Brain White Matter Microstructure Jun 17, 2021 New ALS Risk Gene Suggests Role for Apoptosis Jun 15, 2021 Autism Sharing Initiative Brings Federated Data Model to Research, Clinical Care Premium Jun 15, 2021 Study Explores Usefulness of NfL as Biomarker Across Range of Neurological Conditions Premium Jun 14, 2021 Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Jun 10, 2021 Alzheimer's Disease Meta-Analysis Identifies Novel Differentially Methylated Loci May 27, 2021 Large-Scale Depression Genetic Study Uncovers Additional Risk Loci, Ties to Potential Drugs May 26, 2021 23andMe Begins Reporting PGx Variants With Drug Info Under Recent FDA Clearance Premium May 21, 2021 NIH, Genomics England Launch Large-Scale Human Genome Sequencing Studies Using Nanopore Technology May 21, 2021 European Project to Harness Biobanks, EHRs to Develop Precision Psychiatry Tools Premium May 20, 2021 Rabid-Seq Method Offers NGS-Based View of Cellular Interactions in the Brain Premium May 19, 2021 Analysis Uncovers Hundreds of Autism-Linked Genes Using Evolution-Informed Approach May 17, 2021 Bipolar Disorder GWAS Meta-Analysis Points to Potential Treatment Targets Load More Breaking News Exome Sequencing of UK Biobank Participants Highlights Natural Variation, Gene Function Cystic Fibrosis Sinus Infections Involve Microbes With Shifting Evolution Patterns Molecular Assemblies Wins $256K NIH Phase I SBIR Grant to Develop Enzymatic DNA Synthesis Vibrent Health, VCU Partner to Offer Twin Research Platform Castle Biosciences Acquires Cernostics for up to $80M Princess Margaret Cancer Centre, Inivata Partner on Clinical Liquid Biopsy Studies The Scan Could Mix It Up The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says. Closest to the Dog New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs. Offer to Come Back The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back. PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication In PNAS this week: role of microRNAs in myeloid differentiation, exosomes in urine, and more.