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Booster Boosts

People who received the Johnson & Johnson SARS-CoV-2 vaccine may have a stronger immune response when given a booster of either the Pfizer-BioNTech or Moderna vaccines, as compared to another J&J dose, NPR reports.

The National Institutes of Health-funded "mix and match" study, which has been posted to MedRxiv, enrolled 458 individuals who had previously been vaccinated with the Pfizer-BioNTech, Moderna, or J&J SARS-CoV-2 vaccines. Participants then received a booster dose of one of the three vaccines — not necessarily the same one they previously received. According to the researchers' analysis, all the boosters were immunogenic. They note, though, an mRNA-based booster led to a higher neutralizing response, particularly among individuals who had received an initial J&J vaccine.

The researchers caution, though, that their study was not designed to compare different responses and had a limited follow-up time.

As Business Insider notes, the study results come as a US Food and Drug Administration advisory panel is to meet to discuss boosters of the J&J and Moderna SARS-CoV-2 vaccines.

The Scan

Could Mix It Up

The US Food and Drug Administration is considering a plan that would allow for the mixing-and-matching of SARS-CoV-2 vaccines and boosters, the New York Times says.

Closest to the Dog

New Scientist reports that extinct Japanese wolf appears to be the closest known wild relative of dogs.

Offer to Come Back

The Knoxville News Sentinel reports that the University of Tennessee is offering Anming Hu, a professor who was acquitted of charges that he hid ties to China, his position back.

PNAS Papers on Myeloid Differentiation MicroRNAs, Urinary Exosomes, Maize Domestication

In PNAS this week: role of microRNAs in myeloid differentiation, exosomes in urine, and more.